"Let us pray that the will to resume dialogue may prevail between the parties and that a negotiated solution can finally be reached, one that would allow the peaceful coexistence of two states within mutually agreed and internationally recognized borders," Francis said.
Pope Francis used his Christmas message on Monday to call for a negotiated two-state solution to end the Israeli-Palestinian conflict, after U.S. President Donald Trump stoked regional tensions with his recognition of Jerusalem as Israel's capital.
It was the second time that the pope has spoken out publicly about Jerusalem since Trump's decision on Dec. 6. On that day, Francis called for the city's "status quo" to be respected, lest new tensions in the Middle East further inflame world conflicts.
The pope also called for "mutual trust" on the Korean peninsula as he highlighted the suffering of children in conflicts across the world in his Christmas address on Monday.
"Let us pray that confrontation may be overcome on the Korean peninsula and that mutual trust may increase in the interest of the world as a whole," Francis said.